Bruce Arena's side are on the back of an impressive nine games unbeaten, but will be without key forwards Gyasi Zardes and Robbie Keane. Both have left for their respective national teams ahead of the starts of the Copa America and UEFA Euro 2016.
But a positive run can only ignite confidence, and depth is one thing the Galaxy have clearly built their early season success from. Giovani dos Santos and Steven Gerrard have been particularly impressive, scoring a combined seven goals and notching four assists.
On the other hand, the Montreal Impact are winless in their last six games. Like the Galaxy, they will be without top defender Lareunt Ciman, who has joined up with the Belgium national team for Euro 2016. Meanwhile, DIdier Drogba is questionable after after missing last week's game with a hip strain.
Of course, the more obvious solution to a possible Drogba absence is Ignacio Piatti, who leads the team with seven goals scored in 12 appearances.
This is only the fifth time these teams meet, and the Impact has never been able to win a game against Galaxy. Bruce Arena and co. will hope it stays that way.
Match date/time: Saturday 8pm EST, 8pm local
Venue: Stade Saputo, Montreal, Canada
TV: Time Warner Cable SportsNet, Time Warner Cable Deportes (Spanish)
Streaming: MLS Live (local blackout)