The Stars and Stripes' debut in Copa America isn't until next Friday against Colombia, but the Galaxy will already be without key forward Gyasi Zardes. Zardes has arguably been one of the Galaxy's best players this season, scoring four times and notching four assists in just ten appearances.
Along with Zardes, Robbie Keane will be unavailable, as the Galaxy captain has joined the Republic of Ireland's national football team for the Euro 2016 tournament.
As such, a note of caution is inevitable. The Galaxy will be without two key players and Bruce Arena will have to adjust just in terms of which players should make up their strike force.
But this year's Galaxy is clearly building their success off their depth. Bruce Arena has Alan Gordon back healthy, and most of the attacking players in his squad will be familiar with their assigned role. In that respect, the Galaxy has already overcame a mini injury crisis earlier in the season that demonstrated just how deep this squad is.
There is also the fact that the Galaxy is a league best nine games unbeaten. The Montreal Impact, on the other hand, are winless in their last six.
Like Keane, Impact defender Laurent Ciman has joined his national team for the Euro 2016, and perhaps most notably, star forward Didier Drogba is questionable for Saturday's game after missing last week's game with a hip strain.
In total, this is only the fifth meeting between the Galaxy and Montreal Impact. Only one game has ended in victory, with the Galaxy taking a 1-0 win back in 2013. Undeniably, the Galaxy will want to get get something here, especially if Drogba is missing.
LA Galaxy 0-0 Montreal Impact - September 13, 2015 - MLS
The Galaxy and Impact settled for a goalless stalemate as Didier Drogba left the game before halftime through injury.
LA Galaxy (4-4-2): Rowe; Rogers, Steres, Van Damme, Cole; Lletget, De Jong, Gerrard, Boateng; Dos Santos, Magee
Montreal Impact (4-2-3-1): Bush; Camara, Lefevbre, Cabrera, Oyongo; Donadel, Bekker; Ontivero, Venegas, Piatti; Oduro