After a long international break, the LA Galaxy travel to Vancouver, Canada seeking their first road win of the season.
Earlier in the week, Bruce Arena's men were stunned with the news that captain Robbie Keane will be sidelined 4-6 weeks after successfully undergoing surgery on his right knee.
Indeed, injuries again are hindering the Galaxy as Keane joins Steven Gerrard and Jeff Larentowicz on Bruce Arena's ever-changing injury list.
One a positive note, however, Dan Kennedy has just recently returned to training after picking up a groin injury in the opening game, and Giovani Dos Santos returned to full training this week and is expected to be available for Saturday's game.
Meanwhile, the Whitecaps arrive to this game on the back of their first home win of the season but will be without Japanese forward Masato Kudo after the MLS Disciplinary Committee suspended the player for simulation.
In total, the Galaxy have not won a game in Vancouver in their last two visits and this presents Bruce Arena's side their only chance to claim an end to that run this MLS regular season.
Match date/time: Saturday 10:00pm EST, 7:00pm local
Venue: BC Place, Vancouver, Canada
TV: Time Warner Cable SportsNet, Time Warner Cable Deportes (Spanish)
Streaming: MLS Live (local blackout)